Genome Editing Core

part of the Genome Editing and Animal Models Facility (GEAM)


GEAM provides support for the generation of novel CRISPR models and for the cryopreservation, rederivation, and maintenance of animal models. A full suite of services is available, including:

  • Generation of mouse, rat, and porcine CRISPR models
  • Efficient generation of genome edited, clonal cell lines
  • Genome-wide CRISPR screening
  • Expert support for custom genome editing applications

Some common services

After consultation with the investigator, CRISPR project design and reagent synthesis is completed. Reagents are injected into rodent embryos, and resultant pups are genotyped. The line can be returned to the investigator while also cryopreserved.

GEAM history

Genome Editing and Animal Models Core (GEAM), formerly Transgenic Animal Facility, was established in 1988 and has a long history of providing UW Madison researchers access to the latest technology for generating transgenic and gene targeted animals at a reasonable cost. We have been nationally recognized for our work in manipulating rat embryos and have been very successful in incorporating CRISPR/Cas9 technology into our program.

GEAM is a Shared Resource of the University of Wisconsin-Madison Carbone Cancer Center.